*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AB5956333
CHEMICAL NAME           : Acetamide,
                          N-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-be
                          nzopyran-4-yl)- N-(phenylmethoxy)-, (3S-trans)-
CAS REGISTRY NUMBER     : 127408-30-4
LAST UPDATED            : 199603
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H22-N2-O4
MOLECULAR WEIGHT        : 366.45
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Y 27152
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   9,372,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   9,372,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   9,372,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 910 mg/kg/13W-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Vascular - BP lowering not characterized in autonomic section
   Endocrine - changes in thymus weight
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   9,372,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 27300 ug/kg/13W-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   CDREEA Cardiovascular Drug Reviews.  (Raven Press, 1185 Avenue of the
   Americas, New York, NY  10036) V.6-    1988-  Volume(issue)/page/year:
   9,372,1991
 
                            *** END OF RECORD ***