*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AB4542550
CHEMICAL NAME           : Acetamide, 2-(2-benzothiazolyloxy)-N-methyl-N-phenyl-
CAS REGISTRY NUMBER     : 73250-68-7
BEILSTEIN REFERENCE NO. : 1143987
LAST UPDATED            : 199612
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C16-H14-N2-O2-S
MOLECULAR WEIGHT        : 298.38
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 2-(1,3-Benzothiazol-2-yloxy)-N-methylacetanilide
   * 2-(2-Benzothiazolyloxy)-N-methyl-N-phenylacetamide
   * FOE 1976
   * Mefenacet
   * NTN 801
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,544,1991
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >94500 ug/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,544,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,544,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1092 mg/kg/13W-C
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in spleen
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 43800 mg/kg/2Y-C
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Blood - changes in spleen
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 263 gm/kg/2Y-C
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5688 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 13,633,1988
 
                            *** END OF RECORD ***