*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AB4349000
CHEMICAL NAME           : Acetamide, 2-amino-N-(1-methyl-1,2-diphenylethyl)-,
                          (+-)-, (E)-2-butenedioate
CAS REGISTRY NUMBER     : 136286-29-8
LAST UPDATED            : 199706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C17-H20-N2-O.xCl-H
MOLECULAR WEIGHT        : 523.61
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (+-)-2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide fumarate
   * FPL 12924 fumarate
   * PR934-423
   * Remacemide fumarate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1255 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPIRE8 Epilepsy Research.  (Elsevier Science Publishers B.V., POB 1527, 1000
   BM, Amsterdam, Netherlands)  V.1-    1987-  Volume(issue)/page/year:
   8,36,1991
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 286 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EPIRE8 Epilepsy Research.  (Elsevier Science Publishers B.V., POB 1527, 1000
   BM, Amsterdam, Netherlands)  V.1-    1987-  Volume(issue)/page/year:
   8,36,1991
 
                            *** END OF RECORD ***