【药物名称】Propafenone hydrochloride, Pronon, Rytmonorm, Rhythmol
化学结构式(Chemical Structure):
参考文献No.345170
标题:Propafenone
作者:Casta馿r, J.; B鋒ring-Kuhmley, S.R.
来源:Drugs Fut 1977,2(5),325
合成路线图解说明:

The condensation of beta-phenyl-2-hydroxypropiophenone sodium salt (I) with 1-chloro-2,3-epoxypropane (A) at 100 C yields beta-phenyl-2-(2',3'-epoxypropoxy)propiophenone (II). which is then treated with n-propylamine (B) also at 100 C.

参考文献No.604480
标题:Zur Pharmakologie von 2'-[2-Hydroxy-3-(propylamino).propoxy]-3-phenylpropiophenon (Propafenon, SA79)-hydrochlorid
作者:Prigge, E.; Hapke, H.J.
来源:Arzneim-Forsch Drug Res 1976,36(10),1849-57
合成路线图解说明:

The condensation of beta-phenyl-2-hydroxypropiophenone sodium salt (I) with 1-chloro-2,3-epoxypropane (A) at 100 C yields beta-phenyl-2-(2',3'-epoxypropoxy)propiophenone (II). which is then treated with n-propylamine (B) also at 100 C.

参考文献No.701087
标题:2-Hydroxy-3-phenylpropiophenone derivatives
作者:Sauchse, R.
来源:AT 308076B; BE 0785318; DE 2001431; FR 2144601; GB 1307455; NL 7208214
合成路线图解说明:

The condensation of beta-phenyl-2-hydroxypropiophenone sodium salt (I) with 1-chloro-2,3-epoxypropane (A) at 100 C yields beta-phenyl-2-(2',3'-epoxypropoxy)propiophenone (II). which is then treated with n-propylamine (B) also at 100 C.

参考文献No.800275
标题:Einflu?des antiarrhythmikus propafenon auf die intrakardiale erregungsleitung
作者:Beck, O.A.; et al.
来源:Z Kardiol 1975,64731-740
合成路线图解说明:

The condensation of beta-phenyl-2-hydroxypropiophenone sodium salt (I) with 1-chloro-2,3-epoxypropane (A) at 100 C yields beta-phenyl-2-(2',3'-epoxypropoxy)propiophenone (II). which is then treated with n-propylamine (B) also at 100 C.

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