By hydrogenation of 1-(2',6'-dimethylphenoxy)-2-propanoxime (I) with H2 over Raney-Ni in methanol.
The addition reaction of 2,6-dimethylphenol (II) to (S)-2-methyloxirane (I) by means of NaOH in acetonitrile gives (S)-1-(2,6-dimethylphenoxy)-2-propanol (III), which is condensed with phthalimide (IV) by means of DEAD and PPh3 (with inversion of configuration) yielding N-[2-(2,6-dimethylphenoxy)-1(R)-methylethyl]phthalimide (V). Finally, this compound is treated with hydrazine and acetic acid in methanol to eliminate the phthalimido group.
The addition reaction of 2,6-dimethylphenol (II) to (R)-2-methyloxirane (I) by means of NaOH in acetonitrile gives (R)-1-(2,6-dimethylphenoxy)-2-propanol (III), which is condensed with phthalimide (IV) by means of DEAD and PPh3 (with inversion of configuration) yielding N-[2-(2,6-dimethylphenoxy)-1(S)-methylethyl]phthalimide (V). Finally, this compound is treated with hydrazine and acetic acid in methanol to eliminate the phthalimido group.