【药物名称】Prazosin hydrochloride, CP-12299-1, Eurex, Hypovase, Minipress
化学结构式(Chemical Structure):
参考文献No.608256
标题:Traceless solid-phase synthesis of 2,4-diaminoquinazolines
作者:Wilson, L.J.
来源:Org Lett 2001,3(4),585
合成路线图解说明:

Treatment of carboxy polystyrene resin (I) with oxalyl chloride in dichloromethane, followed by reaction with Bu4NNCS in THF/DCM, affords isothiocyanate resin (II), to which 2-amino-4,5-dimethoxybenzonitrile (III) is attached by means of NMP to provide derivative (IV). Treatment of resin (IV) with 1-(2-furoyl)-piperazine (V) and EDC in chloroform in the presence of DIEA furnishes resin-bound guanidine (VI), from which prazosin is obtained as its trifluoroacetic acid salt (VII) by acidolysis with TFA/H2O at 80 C. Finally, the hydrochloride salt of prazosin can be obtained by treatment with HCl.

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