Camazepam, Albego-药物合成数据库

【药物名称】Camazepam, Albego

化学结构式(Chemical Structure):

参考文献No.	800742
标题:	Camazepam
作者:	Casta馿r, J.; Bundgaard, H.
来源:	Drugs Fut 1976,1(10),458

合成路线图解说明: The condensation of 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with phenyl chlorocarbonate (II) in pyridine yields 7-chloro-1,3-dihydro-3-phenoxycarbonyl-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (III), m.p. 176-8 C, which is then condensed with dimethylamine.

参考文献No.	800743
标题:	1,4-Benzodiazepine derivatives
作者:	Ferrrari, G.; Casagrande, C.
来源:	DE 2142181; ES 394484; FR 2103475; GB 1327930

合成路线图解说明: The condensation of 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (I) with phenyl chlorocarbonate (II) in pyridine yields 7-chloro-1,3-dihydro-3-phenoxycarbonyl-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (III), m.p. 176-8 C, which is then condensed with dimethylamine.