【药物名称】Lormetazepam, ZK-65997, Wy-4082, Loretam, Noctamid, Loramet
化学结构式(Chemical Structure):
参考文献No.300797
标题:Lormetazepam
作者:Serradell, M.N.; Blancafort, P.; Casta馿r, J.; Owen, R.T.
来源:Drugs Fut 1980,5(10),495
合成路线图解说明:

The reaction of 7-chloro-5-(o-chlorophenyl)-13-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one N-oxide (I) with refluxing acetic anhydride gives 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-acetoxy-1-methyl-2H-1,4-benzodiazepin-2-one (II), which is hydrolyzed with NaOH in ethanol.

参考文献No.700929
标题:Proc閐?de pr閜aration de d閞iv閟 du delta(4,9)-estradi鑞e
作者:Nomine, G.; et al.
来源:CH 416611
合成路线图解说明:

The reaction of 7-chloro-5-(o-chlorophenyl)-13-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one N-oxide (I) with refluxing acetic anhydride gives 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-acetoxy-1-methyl-2H-1,4-benzodiazepin-2-one (II), which is hydrolyzed with NaOH in ethanol.

参考文献No.700930
标题:5-Monocyclicaryl-1-,3-dihydro-2H-1,4-benzodiazepin-2-ones
作者:Bell, S.C.
来源:CH 466297; DE 1445424; NL 298071
合成路线图解说明:

The reaction of 7-chloro-5-(o-chlorophenyl)-13-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one N-oxide (I) with refluxing acetic anhydride gives 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-acetoxy-1-methyl-2H-1,4-benzodiazepin-2-one (II), which is hydrolyzed with NaOH in ethanol.

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