【药物名称】Meclofenamate sodium, CI-853(free acid), Meclodol, Meclomen
化学结构式(Chemical Structure):
参考文献No.277278
标题:Meclofenamic acid
作者:Arrigoni-Martelli, E.; Casta馿r, J.
来源:Drugs Fut 1978,3(4),307
合成路线图解说明:

By condensation of o-bromobenzoic acid (I) with 2,6-dichloro-3-methylaniline (II) by means of CuBr2 in diethylene glycol dimethyl ether containing N-ethylmorpholine and heated at 145-55 C.

参考文献No.701002
标题:Anthranilic acids and derivatives
作者:Scherrer, R.A.; Short, F.W.
来源:US 3313848
合成路线图解说明:

By condensation of o-bromobenzoic acid (I) with 2,6-dichloro-3-methylaniline (II) by means of CuBr2 in diethylene glycol dimethyl ether containing N-ethylmorpholine and heated at 145-55 C.

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