【药物名称】Oxiconazole nitrate, Ro-13-8996/001, Sgd-30176, Okinazole, Oxistat, Myfungar, Oceral
化学结构式(Chemical Structure):
参考文献No.46972
标题:Imidazolyl-oxime ethers having anti-mycotic and bactericidal activity
作者:Mixich, G.; et al. (Siegfried AG)
来源:DE 2657578; FR 2336129; GB 1514870; JP 52102276; US 4124767
合成路线图解说明:

The reaction of 2',4'-dichloro-2-imidazol-1-yl-acetophenone (I) with hydroxylamine (II) in refluxing ethanol pyridine gives the corresponding oxime (III). which is condensed with 2,4-dichlorobenzyl chloride (IV) by means of NaH in hot DMF.

参考文献No.201782
标题:Oxiconazole nitrate
作者:Serradell, M.N.; Blancafort, P.; Hillier, K.; Casta馿r, J.
来源:Drugs Fut 1981,6(2),99
合成路线图解说明:

The reaction of 2',4'-dichloro-2-imidazol-1-yl-acetophenone (I) with hydroxylamine (II) in refluxing ethanol pyridine gives the corresponding oxime (III). which is condensed with 2,4-dichlorobenzyl chloride (IV) by means of NaH in hot DMF.

参考文献No.604481
标题:Ein beitrag zur stereospezifischen Synthese von antimykotisch wirksamen imidazolyloximathern
作者:Thiele, K.; Mixich, G.
来源:Arzneim-Forsch Drug Res 1979,29(10),1510-13
合成路线图解说明:

The reaction of 2',4'-dichloro-2-imidazol-1-yl-acetophenone (I) with hydroxylamine (II) in refluxing ethanol pyridine gives the corresponding oxime (III). which is condensed with 2,4-dichlorobenzyl chloride (IV) by means of NaH in hot DMF.

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