【药物名称】Memantine hydrochloride, SUN-Y7017, NMI-131, D-145, Namenda, Axura, Ebixa, Akatinol
化学结构式(Chemical Structure):
参考文献No.54402
标题:Method for the synthesis of adamantane amines
作者:Kraus, G.A. (Iowa State University)
来源:US 5599998
合成路线图解说明:

The reaction of 1-bromo-3,5-dimethyladamantane (I) with Li in ethyl ether gives the corresponding lithium derivative, which is treated with NH2-Cl (II) to afford the target 1-aminoadamantane.

参考文献No.54585
标题:Process for the preparation of 1,3,5-trisubstd. adamantan derivs.
作者:Peteri, D.; Scherm, A. (Merz Pharmaceuticals GmbH)
来源:DE 2318461
合成路线图解说明:

By heating of 3,5-dimethyl-1-chloroadamantane (I) with urea (II) at 165-85 C.

参考文献No.201786
标题:Memantine
作者:Casta馿r, J.; Thorpe, P.
来源:Drugs Fut 1976,1(9),427
合成路线图解说明:

By heating of 3,5-dimethyl-1-chloroadamantane (I) with urea (II) at 165-85 C.

参考文献No.701133
标题:
作者:Burkhard, J.; Landa, S.
来源:CZ 146405
合成路线图解说明:

By heating of 3,5-dimethyl-1-chloroadamantane (I) with urea (II) at 165-85 C.

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