Domperidone, R-33812, Nauzelin, Motilium-药物合成数据库

【药物名称】Domperidone, R-33812, Nauzelin, Motilium

化学结构式(Chemical Structure):

参考文献No.	199369
标题:	Domperidone
作者:	Casta馿r, J.
来源:	Drugs Fut 1977,2(10),661

合成路线图解说明: By condensation of 1-(3-chloropropyl)-2-benzimidazolinone (I) with 5-chloro-1-(piperidin-4-yl)-2-benzimidazolinone (II) by means of Na2CO3 and KI in 4-methyl-2-pentanone.

参考文献No.	701094
标题:	1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds
作者:	Van Heertum, A.; et al.
来源:	BE 0844087; FR 2361889; JP 61093183; US 4066772

合成路线图解说明: By condensation of 1-(3-chloropropyl)-2-benzimidazolinone (I) with 5-chloro-1-(piperidin-4-yl)-2-benzimidazolinone (II) by means of Na2CO3 and KI in 4-methyl-2-pentanone.