【药物名称】Cefotetan disodium, ICI-156834(free acid), YM-09330, Cefotan, Apatef, Yamatetan
化学结构式(Chemical Structure):
参考文献No.199347
标题:Cefotetan
作者:Blancafort, P.; Casta馿r, J.; Sweetman, A.J.; Serradell, M.N.
来源:Drugs Fut 1981,6(10),609
合成路线图解说明:

The condensation of 4-carboxy-3-hydroxy-5-mercaptoisothiazol (I) with 7beta-bromoacetamido-7alpha-methoxycephalosporanic acid (II) gives 7beta-(4-carboxy-3-hydroxyisothiazol-5-yl)thioacetamido-7alpha-methoxycephalosporanic acid (III), which by treatment with NaHCO3 in hot water is converted into 7beta-[4-(carbamoyl)(carboxy)methylene-1,3-dithietan-2-yl]carboxamido-7alpha-methoxycephalosporanic acid (IV). Finally, this compound is condensed with 5-mercapto-1-methyltetrazol (V) by means of Na2CO3 in water.

参考文献No.700881
标题:7alpha-Methoxy-7beta-(1,3-dithietane-2-carboxamido)cephalosporanic acid derivatives
作者:Iwanami, M.; Maeda, T.; Nagano, Y.; Fujimoto, M.; Nagano, N.; Yamazaki, A.
来源:BE 0867994; DE 2824559; FR 2405952; NL 7806208; US 4263432; US 4404373
合成路线图解说明:

The condensation of 4-carboxy-3-hydroxy-5-mercaptoisothiazol (I) with 7beta-bromoacetamido-7alpha-methoxycephalosporanic acid (II) gives 7beta-(4-carboxy-3-hydroxyisothiazol-5-yl)thioacetamido-7alpha-methoxycephalosporanic acid (III), which by treatment with NaHCO3 in hot water is converted into 7beta-[4-(carbamoyl)(carboxy)methylene-1,3-dithietan-2-yl]carboxamido-7alpha-methoxycephalosporanic acid (IV). Finally, this compound is condensed with 5-mercapto-1-methyltetrazol (V) by means of Na2CO3 in water.

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