Pineprofen, Ibuprofen piconol, BE-100, Vesicum, Staderm-药物合成数据库

【药物名称】Pineprofen, Ibuprofen piconol, BE-100, Vesicum, Staderm

化学结构式(Chemical Structure):

参考文献No.	46763
标题:	Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic acids and use
作者:	Noda, K.; Nakagawa, A.; Ishikura, Y.; Tosu, S.; Ide, H. (Hisamitsu Pharmaceutical Co., Ltd.)
来源:	US 4150137

合成路线图解说明: This compound can be obtained in two different ways: 1) By reaction of 2-(p-isobutylphenyl)propionic acid sodium salt (I) with 2-pyridylmethyl chloride (II) in refluxing benzene. 2) By reaction of 2-(p-isobutylphenyl)propionyl chloride (III) with 2-pyridylmethanol (IV) by means of triethylamine in THF.

参考文献No.	201763
标题:	Pineprofen
作者:	Casta馿r, J.; Blancafort, P.; Serradell, M.N.
来源:	Drugs Fut 1982,7(6),401

合成路线图解说明: This compound can be obtained in two different ways: 1) By reaction of 2-(p-isobutylphenyl)propionic acid sodium salt (I) with 2-pyridylmethyl chloride (II) in refluxing benzene. 2) By reaction of 2-(p-isobutylphenyl)propionyl chloride (III) with 2-pyridylmethanol (IV) by means of triethylamine in THF.