【药物名称】Amsacrine, CI-880, NSC-141549(HCl), SN-11841, NSC-249992, NSC-156303, m-AMSA, Amsidyl, Amecrin, Amsidine
化学结构式(Chemical Structure):
参考文献No.154683
标题:m-AMSA
作者:Paton, D.M.; Blancafort, P.; Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1980,5(6),277
合成路线图解说明:

The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II), which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) . Finally, this compound is condensed with 9-chloroacridine (IV).

参考文献No.607165
标题:Potential antitumor agents. 23. 4'-(9-Acridinylamino)alkanesulfonanilide congeners bearing hydrophilic functionality
作者:Cain, B.F.; Atwell, G.J.; Denny, W.A.
来源:J Med Chem 1977,20(8),987-996
合成路线图解说明:

The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II), which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) . Finally, this compound is condensed with 9-chloroacridine (IV).

参考文献No.607980
标题:Potential antitumor agents. 16. 4-(Acridin-9-ylamino)methanesulfonanilides
作者:Cain, B.F.; Atwell, G.J.; Denny, W.A.
来源:J Med Chem 1975,18(11),1110-17
合成路线图解说明:

The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II), which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) . Finally, this compound is condensed with 9-chloroacridine (IV).

参考文献No.800229
标题:Potential antitumor agents. 26. Anionic congeners of the 9-anilinoacridine
作者:Denny, W.A.; et al.
来源:J Med Chem 1977,21(1),5-10
合成路线图解说明:

The reaction of 4-nitro-m-anisidine (I) with methanesulfonyl chloride in pyridine gives 4-nitromethanesulfony-m-anisidine (II), which is reduced with Fe and aqueous HCl yielding 4-aminomethanesulfony-m-anisidine (III) . Finally, this compound is condensed with 9-chloroacridine (IV).

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us