【药物名称】Ibuprofen guaiacol ester, AF-2259, Benflogin
化学结构式(Chemical Structure):
参考文献No.46999
标题:Guaiacol p-isobutyl hydratropate
作者:Baiochi, L.; Silvestrini, B. (ACRAF SpA)
来源:DE 2726435; FR 2357526; GB 1538636; JP 53025536; US 4134989
合成路线图解说明:

By esterification of guaiacol (II) with 4-isobutylhydratropoyl chloride (I) by means of H2SO4.

参考文献No.154680
标题:AF-2259
作者:Blancafort, P.; Casta馿r, J.; de Angelis, L.; Serradell, M.N.
来源:Drugs Fut 1980,5(11),539
合成路线图解说明:

By esterification of guaiacol (II) with 4-isobutylhydratropoyl chloride (I) by means of H2SO4.

参考文献No.700927
标题:Proceso para la preparaci髇 de p-isobutil-hidratropato de guayacol
作者:Baiochi, L.; Silvestrini, B.
来源:ES 464502
合成路线图解说明:

By esterification of guaiacol (II) with 4-isobutylhydratropoyl chloride (I) by means of H2SO4.

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