【药物名称】Divalproex sodium, Valproate semisodium, Abbott-50711, Cereb, Epival, Depakote, D閜akine Chrono
化学结构式(Chemical Structure):
参考文献No.43204
标题:Process for preparing an acetonitrile deriv.
作者:Chignac, M.; Grain, C.; Pigerol, C. (Labaz)
来源:GB 1522450
合成路线图解说明:

This compound has been obtained by two different ways: 1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II), which is treated with KCN to yield 2-propylpentanenitrile (III). Finally, this compound is hydrolyzed to the target compound with NaOH or with H2SO4. 2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester, which, without isolation, is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI). The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).

参考文献No.43205
标题:Process for preparing acetic acid derivs.
作者:Pigerol, C.; Grain, C.; Chignac, M. (Labaz)
来源:GB 1529786
合成路线图解说明:

This compound has been obtained by two different ways: 1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II), which is treated with KCN to yield 2-propylpentanenitrile (III). Finally, this compound is hydrolyzed to the target compound with NaOH or with H2SO4. 2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester, which, without isolation, is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI). The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).

参考文献No.43206
标题:Process for the preparation of acetonitrile deriv.
作者:Grain, C.; Chignac, M.; Pigerol, C. (Labaz)
来源:US 4155929
合成路线图解说明:

This compound has been obtained by two different ways: 1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II), which is treated with KCN to yield 2-propylpentanenitrile (III). Finally, this compound is hydrolyzed to the target compound with NaOH or with H2SO4. 2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester, which, without isolation, is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI). The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).

参考文献No.701149
标题:
作者:Walles, M.; et al.
来源:Z Physiolog Chem 1947,282(2),137
合成路线图解说明:

This compound has been obtained by two different ways: 1) The reaction of dipropylcarbinol (I) with HBr gives 4-bromoheptane (II), which is treated with KCN to yield 2-propylpentanenitrile (III). Finally, this compound is hydrolyzed to the target compound with NaOH or with H2SO4. 2) The condensation of cyanacetic acid ethyl ester (IV) with propyl bromide (V) by means of sodium propoxide in propanol gives crude dipropylcyanaacetic acid ethyl ester, which, without isolation, is hydrolyzed with NaOH in hot water yielding dipropylcyanacetic acid (VI). The decarboxylation of (VI) at 140-190 C affords the previously reported 2-propylpentanenitrile (III).

参考文献No.701188
标题:Process for making sodium hydrogen divalproate
作者:Fischer, F.E.
来源:AR 226077; CA 1144558; GR 70721
合成路线图解说明:

By reaction of valproic acid (I) with NaOH in water - acetonitrile (II).

参考文献No.800321
标题:Valproate semisodium
作者:Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1984,9(8),595
合成路线图解说明:

By reaction of valproic acid (I) with NaOH in water - acetonitrile (II).

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