【药物名称】Butibufen, FF-106, Butilop醤, Mijal
化学结构式(Chemical Structure):
参考文献No.154662
标题:Butibufen
作者:Aparicio, L.
来源:Drugs Fut 1977,2(3),156
合成路线图解说明:

Several methods for obtaining this compoud have been described: 1) By treating the 4-isobutyl phenyl acetonitrile (I) with sodium amide and ethyl iodide, followed by the hydrolysis of the reaction product (II). 2) The reaction of the nitrile (I) with sodium ethoxide and diethyl carbonate leads to the cyanoacetic ester (III), which is treated with ethyl iodide; thus (IV) being obtained, the hydrolysis and decarboxylation of (IV) leads to the final acid. 3) The alkaline hydrolysis of the 4-isobutyl phenyl acetonitrile (I) leads to 4-isobutyl phenyl acetic acid (V). This product after treatment with Na in naphthalene and ethyl iodide (A) yields the required compound.

参考文献No.701065
标题:Procedimiento para la obtenci髇 del 醕ido 2-(4'-isobutifenil)but韗ico
作者:Aparicio, L.; et al.
来源:ES 427197; ES 435173; ES 435174
合成路线图解说明:

Several methods for obtaining this compoud have been described: 1) By treating the 4-isobutyl phenyl acetonitrile (I) with sodium amide and ethyl iodide, followed by the hydrolysis of the reaction product (II). 2) The reaction of the nitrile (I) with sodium ethoxide and diethyl carbonate leads to the cyanoacetic ester (III), which is treated with ethyl iodide; thus (IV) being obtained, the hydrolysis and decarboxylation of (IV) leads to the final acid. 3) The alkaline hydrolysis of the 4-isobutyl phenyl acetonitrile (I) leads to 4-isobutyl phenyl acetic acid (V). This product after treatment with Na in naphthalene and ethyl iodide (A) yields the required compound.

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