【药物名称】Ivarimod, Ru-18492
化学结构式(Chemical Structure):
参考文献No.47810
标题:Novel derivatives of maleopimaric acid
作者:Taylor, J.B.; et al. (Aventis Pharma SA)
来源:DE 2351343; FR 2202691; GB 1417996; JP 49093356; US 3998823
合成路线图解说明:

The reaction of maleopimaric acid (I) with SOCl2 in benzene produces the corresponding acyl chloride (V), which is then condensed with morpholine (A) by means of Et3N in benzene yielding maleopimaryl morpholide (VI). Finally, (VI) is condensed with ethanolamine (B) in refluxing ethanol.

参考文献No.86207
标题:RU 18492
作者:Thorpe, P.; Casta馿r, J.
来源:Drugs Fut 1977,2(9),623
合成路线图解说明:

The reaction of maleopimaric acid (I) with aqueous ammonia and heating at 170 C gives maleopimarimide (II), which by reaction with oxalyl chloride in benzene is converted into the corresponding acyl chloride (III). The reaction of (III) with morpholine (A) in benzene yields maleopimarimidyl morpholide (IV), which is finally condensed with ethanolamine (B) in refluxing methanol.

合成路线图解说明:

The reaction of maleopimaric acid (I) with SOCl2 in benzene produces the corresponding acyl chloride (V), which is then condensed with morpholine (A) by means of Et3N in benzene yielding maleopimaryl morpholide (VI). Finally, (VI) is condensed with ethanolamine (B) in refluxing ethanol.

参考文献No.604505
标题:hepatoprotective agents. II. Maleopimaridyl morpholides
作者:Danswan, G.W.; Ramm, P.J.; Matharu, S.; Taylor, J.B.
来源:Arzneim-Forsch Drug Res 1976,26(12),2190-92
合成路线图解说明:

The reaction of maleopimaric acid (I) with aqueous ammonia and heating at 170 C gives maleopimarimide (II), which by reaction with oxalyl chloride in benzene is converted into the corresponding acyl chloride (III). The reaction of (III) with morpholine (A) in benzene yields maleopimarimidyl morpholide (IV), which is finally condensed with ethanolamine (B) in refluxing methanol.

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