【药物名称】Traxanox sodium, Y-12141, Clearnal
化学结构式(Chemical Structure):
参考文献No.79474
标题:Y-12141
作者:Casta馿r, J.; Hillier, K.
来源:Drugs Fut 1980,5(5),261
合成路线图解说明:

This compound can be prepared by two related ways: 1) The condensation of 2-chloronicotinic acid (I) with 3-chloro-4-hydroxybenzonitrile (II) by means of sodium methoxide in nitrobenzene at 180 C gives 2-(2-chloro-4-cyanophenoxy)nicotinic acid (III), which by reaction with sodium azide in DMF at 100 C is converted into 2-[2-chloro-4(1H)-tetrazol-5-yl)phenoxy]nicotinic acid (IV). Finally, this compound is cyclized with H2SO4 at 180 C. 2) The cylization of gives 2-(2-chloro-4-cyanophenoxy)nicotinic acid (III) with H2SO4 at 180 C gives 9-chloro-5-oxo-5H-[1]benzopyrano[2,3]pyridine-4-carbonitrile (V) , which is then treated with sodium azide.

参考文献No.701395
标题:
作者:Ohe, T.; Tsuruda, M.
来源:US 4085111
合成路线图解说明:

This compound can be prepared by two related ways: 1) The condensation of 2-chloronicotinic acid (I) with 3-chloro-4-hydroxybenzonitrile (II) by means of sodium methoxide in nitrobenzene at 180 C gives 2-(2-chloro-4-cyanophenoxy)nicotinic acid (III), which by reaction with sodium azide in DMF at 100 C is converted into 2-[2-chloro-4(1H)-tetrazol-5-yl)phenoxy]nicotinic acid (IV). Finally, this compound is cyclized with H2SO4 at 180 C. 2) The cylization of gives 2-(2-chloro-4-cyanophenoxy)nicotinic acid (III) with H2SO4 at 180 C gives 9-chloro-5-oxo-5H-[1]benzopyrano[2,3]pyridine-4-carbonitrile (V) , which is then treated with sodium azide.

参考文献No.701396
标题:
作者:Ohe, T.; Tsuruda, M.
来源:JP 76113899
合成路线图解说明:

This compound can be prepared by two related ways: 1) The condensation of 2-chloronicotinic acid (I) with 3-chloro-4-hydroxybenzonitrile (II) by means of sodium methoxide in nitrobenzene at 180 C gives 2-(2-chloro-4-cyanophenoxy)nicotinic acid (III), which by reaction with sodium azide in DMF at 100 C is converted into 2-[2-chloro-4(1H)-tetrazol-5-yl)phenoxy]nicotinic acid (IV). Finally, this compound is cyclized with H2SO4 at 180 C. 2) The cylization of gives 2-(2-chloro-4-cyanophenoxy)nicotinic acid (III) with H2SO4 at 180 C gives 9-chloro-5-oxo-5H-[1]benzopyrano[2,3]pyridine-4-carbonitrile (V) , which is then treated with sodium azide.

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