【药物名称】Gallopamil hydrochloride, D-600, Algocor, Procorum
化学结构式(Chemical Structure):
参考文献No.46551
标题:Verfahren zur herstellung basisch substituerter phenylacetonitrile
作者:Dengel, F. (Knoll AG)
来源:DE 1154810; DE 1158083
合成路线图解说明:

Gallopamil is obtained by condensing 2-(3,4,5-trimethoxypheny)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-(2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) in the presence of bases. Compound (I) can be prepared by reaction of 3,4,5-trimethoxyphenylacetonitrile (III) with isopropyl chloride (IV) by means of NaNH2. Compound (II) is formed from 1-bromo-3-chloropropane (V) and N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (VI).

参考文献No.80300
标题:Gallopamil Hydrochloride
作者:Mannhold, R.
来源:Drugs Fut 1984,9(2),108
合成路线图解说明:

Gallopamil is obtained by condensing 2-(3,4,5-trimethoxypheny)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-(2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) in the presence of bases. Compound (I) can be prepared by reaction of 3,4,5-trimethoxyphenylacetonitrile (III) with isopropyl chloride (IV) by means of NaNH2. Compound (II) is formed from 1-bromo-3-chloropropane (V) and N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (VI).

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