【药物名称】Glutaurine, Litoralon
化学结构式(Chemical Structure):
参考文献No.46044
标题:Method of preparing gamma-L-glutamyl taurine
作者:Feuer, L.; et al. (Chinoin Pharmaceutical and Chemical Works Co., Ltd.)
来源:US 4110441
合成路线图解说明:

N-carbobenzyloxy-L-glutamic acid (I) is converted to the anhydride (II). Reaction of (II) with benzyl alcohol gives a mixture of half esters from which the halt ester (III) is isolated as the dicyclohexylamine salt. (III) is esterified with 4-nitrophenol (IV) with the aid of dicyclohexyl carbodiimide and the product (V) is reacted with taurine (VI). Deprotection of the resulting peptide (VII) by catalytic debenzylation affords glutaurine.

参考文献No.70590
标题:Glutaurine
作者:N骻r醖i, M.
来源:Drugs Fut 1984,9(2),110
合成路线图解说明:

N-carbobenzyloxy-L-glutamic acid (I) is converted to the anhydride (II). Reaction of (II) with benzyl alcohol gives a mixture of half esters from which the halt ester (III) is isolated as the dicyclohexylamine salt. (III) is esterified with 4-nitrophenol (IV) with the aid of dicyclohexyl carbodiimide and the product (V) is reacted with taurine (VI). Deprotection of the resulting peptide (VII) by catalytic debenzylation affords glutaurine.

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