【药物名称】Moxadolen, Lu-253
化学结构式(Chemical Structure):
参考文献No.47486
标题:Carbamates and their use as pharmaceuticals
作者:Ammann, A.; et al. (BASF AG)
来源:US 3965119
合成路线图解说明:

This compound can be obtained in two different ways: 1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF. 2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.

参考文献No.70588
标题:LU-253
作者:Blancafort, P.; Neuman, M.; Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1981,6(2),89
合成路线图解说明:

This compound can be obtained in two different ways: 1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF. 2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.

参考文献No.701352
标题:
作者:Wiersdorff, W.W.; Wilsmann, K.
来源:DE 2510714
合成路线图解说明:

This compound can be obtained in two different ways: 1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF. 2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.

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