【药物名称】TetramethylHES
化学结构式(Chemical Structure):
参考文献No.66951
标题:Tetramethylhes
作者:Hartmann, R.W.
来源:Drugs Fut 1985,10(1),48
合成路线图解说明:

The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide. The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.

参考文献No.547071
标题:Simplified method for the titanium (II)-induced coupling of allylic and benzylic alcohols
作者:Silvestri, M.A.; McMurry, J.E.
来源:J Org Chem 1975,402687
合成路线图解说明:

The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide. The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.

合成路线图解说明:

The synthesis of D-18954 is performed using dimethyl(2-fluoro-4-methoxy-phenyl)carbinol (I) as educt. The tertiary alcohol (I) can be obtained by Grignard reaction of 2-fluoro-4-methoxyacetophenone with methyl magnesium iodide. The dibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3-LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is accomplished with BBr3 and gives D-18954.

参考文献No.607196
标题:Antiestrogens. Synthesis and evaluation of mammary tumor inhibiting activity of 1,1,2,2-tetraalkyl-1,2-diphenylethanes
作者:Hartmann, R.W.; Kranzfelder, G.; Angerer, E.; Sch鰊enberger, H.
来源:J Med Chem 1980,23(8),841-844
合成路线图解说明:

The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide. The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.

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