【药物名称】Detomidine hydrochloride, Domosedan
化学结构式(Chemical Structure):
参考文献No.45859
标题:4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and use as medicaments
作者:Karjalainen, A.J.; Kurkela, K.O.A. (Orion Corporation)
来源:DD 152548; EP 0024829; JP 56032463; US 4443466
合成路线图解说明:

The Grignard condensation of imidazole-4-carboxaldehyde (I) with 2,3-dimethylphenylmagnesium bromide (II) in THF gives 4-(alpha-hydroxy-2,3-dimethylbenzyl)imidazole (III), which is then hydrogenated with H2 over Pd/C in aqueous 4N HCl.

参考文献No.66955
标题:Detomidine Hydrochloride
作者:Casta馿r, J.; Serradell, M.N.
来源:Drugs Fut 1985,10(1),17
合成路线图解说明:

The Grignard condensation of imidazole-4-carboxaldehyde (I) with 2,3-dimethylphenylmagnesium bromide (II) in THF gives 4-(alpha-hydroxy-2,3-dimethylbenzyl)imidazole (III), which is then hydrogenated with H2 over Pd/C in aqueous 4N HCl.

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