Meteneprost, U-46785-药物合成数据库

【药物名称】Meteneprost, U-46785

化学结构式(Chemical Structure):

参考文献No.	60598
标题:	Meteneprost
作者:	Hillier, K.; Casta馿r, J.
来源:	Drugs Fut 1981,6(11),686

合成路线图解说明: The reaction of 16,16-dimethyl-PGE2 methyl ester bis(trimethylsilyl) ether (I) with the reaction product of N,S-dimethyl-S-phenylsulfoximine and methylmagnesium chloride (II) in THF at -78 C followed by a treatment with AlHg and acetic acid gives 9-deoxy-9-methylene-16,16-dimethyl-PGE2 methyl ester (III), which is hydrolyzed with KOH in methanol - water.

参考文献No.	701492
标题:
作者:	Bundy, G.L.
来源:	US 4060534

合成路线图解说明: The reaction of 16,16-dimethyl-PGE2 methyl ester bis(trimethylsilyl) ether (I) with the reaction product of N,S-dimethyl-S-phenylsulfoximine and methylmagnesium chloride (II) in THF at -78 C followed by a treatment with AlHg and acetic acid gives 9-deoxy-9-methylene-16,16-dimethyl-PGE2 methyl ester (III), which is hydrolyzed with KOH in methanol - water.