【药物名称】8-OH-DPAT HBr
化学结构式(Chemical Structure):
参考文献No.60594
标题:8-OH-DPAT Hydrobromide
作者:Arvidsson, L.-E.
来源:Drugs Fut 1985,10(11),916
合成路线图解说明:

8-OH-DPAT is conveniently prepared from 8-methoxy-2-tetralone (I) (1-3). Reductive amination of (I) gives 8-methoxy-2-(n-propylamino)tetralin (II). Subsequent N-acylation using propionyl chloride followed by LiAlH4 reduction yields 8-methoxy-2-(di-n-propylamino)tetralin (III). The title compound is obtained as the hydrobromide after O-demethylation of (III) in aqueous HBr.

参考文献No.607586
标题:8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist
作者:Arvidsson, L.E.; Hacksell, U.; Nilsson, J.L.G.; Hjorth, S.; Carlsson, A.; Lindberg, P.; Sanchez, D.; Wikstr鰉, H.
来源:J Med Chem 1981,24(8),921-923
合成路线图解说明:

8-OH-DPAT is conveniently prepared from 8-methoxy-2-tetralone (I) (1-3). Reductive amination of (I) gives 8-methoxy-2-(n-propylamino)tetralin (II). Subsequent N-acylation using propionyl chloride followed by LiAlH4 reduction yields 8-methoxy-2-(di-n-propylamino)tetralin (III). The title compound is obtained as the hydrobromide after O-demethylation of (III) in aqueous HBr.

参考文献No.608294
标题:8-Hydroxy-2-(alkylamino)tetralins and related compounds as central 5-hydroxytyptamine receptor agonist
作者:Arvidsson, L.E.; Hacksell, U.; Johansson, A.M.; Nilsson, J.L.G.; Lindberg, P.; Sanchez, D.; Wikstr鰉, H.; Svensson, K.; Hjorth, S.; Carlsson, A.
来源:J Med Chem 1984,27(1),45-51
合成路线图解说明:

8-OH-DPAT is conveniently prepared from 8-methoxy-2-tetralone (I) (1-3). Reductive amination of (I) gives 8-methoxy-2-(n-propylamino)tetralin (II). Subsequent N-acylation using propionyl chloride followed by LiAlH4 reduction yields 8-methoxy-2-(di-n-propylamino)tetralin (III). The title compound is obtained as the hydrobromide after O-demethylation of (III) in aqueous HBr.

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