Milrinone lactate, YM-018, Win-47203, Corotrope, Primacor-药物合成数据库

【药物名称】Milrinone lactate, YM-018, Win-47203, Corotrope, Primacor

化学结构式(Chemical Structure):

参考文献No.	46773
标题:	5-(pyridinyl)-2(1H)-pyridinones, useful as cardiotonic agents and their preparation
作者:	Lehser, G.Y.; Philion, R.E.; Page, D.F.; Opalka, C.J. (Sterling Winthrop Inc.)
来源:	DE 3044568; FR 2470124; GB 2065642; NL 8006399

合成路线图解说明: The condensation of ethyl acetate (I) with 4-picoline (II) by means of n-butyllithium in THF gives 1-(4-pyridyl)propanone (III), which by reaction with the dimethylacetal of dimethylformamide (IV) in refluxing HMPT is converted into 4-dimethylamino-3-(4-pyridyl)-3-buten-2-one (V). Finally, this compound is cyclized with cyanacetamide (VI) by means of sodium methoxide in refluxing DMF.

参考文献No.	60599
标题:	WIN-47,203
作者:	Serradell, M.N.; Casta馿r, J.; Blancafort, P.
来源:	Drugs Fut 1982,7(10),757

合成路线图解说明: The condensation of ethyl acetate (I) with 4-picoline (II) by means of n-butyllithium in THF gives 1-(4-pyridyl)propanone (III), which by reaction with the dimethylacetal of dimethylformamide (IV) in refluxing HMPT is converted into 4-dimethylamino-3-(4-pyridyl)-3-buten-2-one (V). Finally, this compound is cyclized with cyanacetamide (VI) by means of sodium methoxide in refluxing DMF.