Vinzolidine sulfate, LY-104208-药物合成数据库

【药物名称】Vinzolidine sulfate, LY-104208

化学结构式(Chemical Structure):

参考文献No.	75156
标题:	Vinzolidine Sulfate
作者:	Hopkins, S.J.
来源:	Drugs Fut 1984,9(12),913

合成路线图解说明: The reaction of vinblastine (I) with 2-chloroethyl isocyanate (II) in refluxing benzene gives the corresponding N-(2-chloroethyl)carbamate (III), which is cyclized by continuous refluxing in the same solvent.

参考文献No.	701189
标题:	Oxazolidinedione derivatives of Vinca alkaloids
作者:	Miller, J.C.; Gutowski, G.E.
来源:	FR 2372839; GB 1590649; JP 53071100; US 4096148

合成路线图解说明: The reaction of vinblastine (I) with 2-chloroethyl isocyanate (II) in refluxing benzene gives the corresponding N-(2-chloroethyl)carbamate (III), which is cyclized by continuous refluxing in the same solvent.