【药物名称】Mebrofenin, SQ-26962, Choletec
化学结构式(Chemical Structure):
参考文献No.45873
标题:N-substituted iminodiacetic acids
作者:Nunn, A.; Loberg, M. (Bristol-Myers Squibb Co.)
来源:BE 0891534; DE 3151686; FR 2497197; GB 2090252; JP 2160727; JP 58000948
合成路线图解说明:

The bromination of 2,4,6-trimethylaniline (I) with Br2 in aqueous HCl gives 3-bromo-2,4,6-trimethyl-aniline (II), which is then condensed with nitrilotriacetic acid (III) by means of pyridine and acetic anhydride.

参考文献No.61889
标题:5H-Pyrano[2,3-d:6,5-d']dipyrimidine derivs. having an antibacterial, antiviral and immuno-modulating activity
作者:Ashkinazi, R.I. (Natural Drug Sciences LLC)
来源:EP 1033369; US 6340755; WO 9925718
合成路线图解说明:

The bromination of 2,4,6-trimethylaniline (I) with Br2 in aqueous HCl gives 3-bromo-2,4,6-trimethyl-aniline (II), which is then condensed with nitrilotriacetic acid (III) by means of pyridine and acetic anhydride.

合成路线图解说明:

The title pyranodipyrimidine derivative is prepared by cyclization of 4-nitrobenzylidene bis-thiobarbituric acid pyridine salt (I) employing either trifluoroacetic anhydride at 30-40 C or in lower yields with acetic anhydride at 70-80 C. The cyclization of is also carried out in the presence of POCl3/P2O5 in refluxing chloroform.

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