【药物名称】Piroximone, MDL-19205
化学结构式(Chemical Structure):
参考文献No.75166
标题:Piroximone
作者:Mannhold, R.
来源:Drugs Fut 1984,9(12),905
合成路线图解说明:

The acid chloride (II) of isonicotinic acid is prepared by reaction of oxalyl chloride (A) with the potassium salt of isonicotinic acid (I). The acylation of 1,3-dihydro-4-ethyl-2H-imidazol-2-one (III) with acid chloride (II) under Friedel-Crafts' conditions gives 1,3-dihydro-4-isonicotinoyl-5-ethyl-2H-imidazol-2-one.

参考文献No.701196
标题:4-Pyridylimidazolones and method of use
作者:Schnettler, R.A.; Dage, R.C.; Grisar, J.M.; Palopoli, F.P.
来源:EP 0059948; ES 8305352; ES 8402827; GB 2096600; US 4405628
合成路线图解说明:

The acid chloride (II) of isonicotinic acid is prepared by reaction of oxalyl chloride (A) with the potassium salt of isonicotinic acid (I). The acylation of 1,3-dihydro-4-ethyl-2H-imidazol-2-one (III) with acid chloride (II) under Friedel-Crafts' conditions gives 1,3-dihydro-4-isonicotinoyl-5-ethyl-2H-imidazol-2-one.

参考文献No.800316
标题:4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents. Effect of 4-Pyridoyl substituents and related compounds
作者:Dage, R.C.; Schnettler, R.A.; Palopoli, F.P.
来源:186th ACS Natl Meet (Aug. 28 - Sept. 2, Washington, D.C.) 1983,Abst MEDI-84
合成路线图解说明:

The acid chloride (II) of isonicotinic acid is prepared by reaction of oxalyl chloride (A) with the potassium salt of isonicotinic acid (I). The acylation of 1,3-dihydro-4-ethyl-2H-imidazol-2-one (III) with acid chloride (II) under Friedel-Crafts' conditions gives 1,3-dihydro-4-isonicotinoyl-5-ethyl-2H-imidazol-2-one.

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