【药物名称】Tiamenidine, Hoe-42-440(HCl), Hoe-440, Symcor, Sundralen
化学结构式(Chemical Structure):
参考文献No.61879
标题:Tiamenidine
作者:Casta馿r, J.; Thorpe, P.
来源:Drugs Fut 1976,1(10),502
合成路线图解说明:

The reaction of N-(2-chloro-4-methyl-3-thienyl)thiourea (I) with methyl iodide in methanol gives S-methyl-N-(2-chloro-4-methyl-3-thienyl)isothiouronium iodide (II), m.p. 113-5 C, which is then condensed with ethylenediamine (A) in methanol at 100 C.

参考文献No.701136
标题:2-(Thienyl-3'-amino)1,3-diazacycloalkenes
作者:Rippel, R.; et al.
来源:DE 1941761; FR 2068493; FR 2068505; GB 1312133; US 3758476
合成路线图解说明:

The reaction of N-(2-chloro-4-methyl-3-thienyl)thiourea (I) with methyl iodide in methanol gives S-methyl-N-(2-chloro-4-methyl-3-thienyl)isothiouronium iodide (II), m.p. 113-5 C, which is then condensed with ethylenediamine (A) in methanol at 100 C.

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