Gammaphos, Ethiofos(former USAN), Amifostine hydrate, SAPEP, YM-08310, NSC-296961, WR-2721, Ethyol-药物合成数据库

【药物名称】Gammaphos, Ethiofos(former USAN), Amifostine hydrate, SAPEP, YM-08310, NSC-296961, WR-2721, Ethyol

化学结构式(Chemical Structure):

参考文献No.	75300
标题:	SAPEP
作者:	Tabachnik, N.F.; Cerami, A.
来源:	Drugs Fut 1980,5(11),558

合成路线图解说明: 1-(3-Aminopropyl)aziridine (IV) is converted to N-(2-bromoethyl)-1,3-propanediamine dihydrobromide (V) by the addition of HBr. (V) is converted to the thiophosphate WR-2721 (VI) with trisodium thiophosphoroate.

参考文献No.	700912
标题:
作者:	Love-Gregory, L.; Permutt, M.; Suarez, B.; Wasson, J.; Lin, J.; Sklonick, G.
来源:	Walter Reed Army Inst. of Research, Food and Drug Administration IND #5509 1968,Abst 1618

合成路线图解说明: 1-(3-Aminopropyl)aziridine (IV) is converted to N-(2-bromoethyl)-1,3-propanediamine dihydrobromide (V) by the addition of HBr. (V) is converted to the thiophosphate WR-2721 (VI) with trisodium thiophosphoroate.