【药物名称】Teroxirone, NSC-296934, alpha-TGT, alpha-TGI
化学结构式(Chemical Structure):
参考文献No.47232
标题:Therapeutic compsns. with a cytostatic action
作者:Schnegelberger, H.; Budnowski, M. (Henkel KgA)
来源:GB 2044614
合成路线图解说明:

The compound can be prepared in the following way: The reaction of a large excess of epichlorohydrin (II) with cyanuric acid (I) at a temperature above 60 C leads to the 1,3,5-tris(oxiranylmethyl)-substituted derivative (III). Thus, epichlorohydrin functions both as alkylating agent and base. The addition of sodium hydroxide accelerates and completes the hydrogen chloride abstraction after the first step of the reaction. Fractional crystallization of the product gives the alpha and beta stereoisomers.

参考文献No.75324
标题:Teroxirone
作者:Casta馿r, J.; Serradell, M.N.; Blancafort, P.
来源:Drugs Fut 1983,8(11),936
合成路线图解说明:

The compound can be prepared in the following way: The reaction of a large excess of epichlorohydrin (II) with cyanuric acid (I) at a temperature above 60 C leads to the 1,3,5-tris(oxiranylmethyl)-substituted derivative (III). Thus, epichlorohydrin functions both as alkylating agent and base. The addition of sodium hydroxide accelerates and completes the hydrogen chloride abstraction after the first step of the reaction. Fractional crystallization of the product gives the alpha and beta stereoisomers.

参考文献No.800365
标题:Preparation and properties of the diastereoisomeic 1,3,5-triglycidyl-s-triazinetriones
作者:Budnowski, M.
来源:Angew Chem 1968,7827
合成路线图解说明:

The compound can be prepared in the following way: The reaction of a large excess of epichlorohydrin (II) with cyanuric acid (I) at a temperature above 60 C leads to the 1,3,5-tris(oxiranylmethyl)-substituted derivative (III). Thus, epichlorohydrin functions both as alkylating agent and base. The addition of sodium hydroxide accelerates and completes the hydrogen chloride abstraction after the first step of the reaction. Fractional crystallization of the product gives the alpha and beta stereoisomers.

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