【药物名称】Idazoxan hydrochloride, RX-781094
化学结构式(Chemical Structure):
参考文献No.47228
标题:Imidazoline deriv.
作者:Chapleo, C.B.; Myers, P.L. (Reckitt & Colman Pharmaceuticals)
来源:GB 2068376
合成路线图解说明:

The cyclization of catechol (I) with 2-chloroacrylonitrile (II) by means of K2CO3 in acetone gives 2-cyanobenzo-1,4-dioxane (III), which is hydrolyzed with ethanol and HCl to the corresponding iminoether (IV) Finally, this compound is cyclized with ethylenediamine (V) in cool ethanol.

参考文献No.49532
标题:Idazoxan hydrochloride
作者:Hillier, K.
来源:Drugs Fut 1983,8(9),778
合成路线图解说明:

The cyclization of catechol (I) with 2-chloroacrylonitrile (II) by means of K2CO3 in acetone gives 2-cyanobenzo-1,4-dioxane (III), which is hydrolyzed with ethanol and HCl to the corresponding iminoether (IV) Finally, this compound is cyclized with ethylenediamine (V) in cool ethanol.

参考文献No.800326
标题:2-[2-(1,4-Benzodioxanyl)]-2-imidazoline hydrochloride
作者:Myers, P.L.; Chapleo, C.B.
来源:Tetrahedron Lett 1981,22(48),4839-42
合成路线图解说明:

The cyclization of catechol (I) with 2-chloroacrylonitrile (II) by means of K2CO3 in acetone gives 2-cyanobenzo-1,4-dioxane (III), which is hydrolyzed with ethanol and HCl to the corresponding iminoether (IV) Finally, this compound is cyclized with ethylenediamine (V) in cool ethanol.

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