Indanidine hydrochloride(Rec INNM), Sgd-10175-药物合成数据库

【药物名称】Indanidine hydrochloride(Rec INNM), Sgd-10175

化学结构式(Chemical Structure):

参考文献No.	47247
标题:	1H- and 2H-indazole derivs. and medicaments containing them
作者:	Molnar, I.; Thiele, K.; Geissmann, F.; Jahn, U. (Siegfried AG)
来源:	EP 0047328

合成路线图解说明: 4-Nitro-2-methylindazole (I) is reduced with H2 over Pd/C in ethyl acetate to give 4-amino-2-methylindazole (II). The condensation of a mixture of 4-amino-2-methylindazole (III) dissolved in tetrahydrofuran and 2-chloroimidazoline (A) in tetrahydrofuran solution in room temperature gives Sgd-101-75.

参考文献No.	66400
标题:	SGD-101-75
作者:	Ismail, S.; Coates, J.; Weetman, D.F.; Chadwick, M.A.; Turner, N.; Lawson, K.; Jahn, U.; Thiele, K.
来源:	Drugs Fut 1983,8(7),603

合成路线图解说明: 4-Nitro-2-methylindazole (I) is reduced with H2 over Pd/C in ethyl acetate to give 4-amino-2-methylindazole (II). The condensation of a mixture of 4-amino-2-methylindazole (III) dissolved in tetrahydrofuran and 2-chloroimidazoline (A) in tetrahydrofuran solution in room temperature gives Sgd-101-75.