【药物名称】Ricainide, Indecainide, LY-135837, Decabid
化学结构式(Chemical Structure):
参考文献No.12474
标题:Neoglucoproteins, their preparation and use
作者:Wiegand, H.; Bosslet, S.; Bosslet, K.; Sedlacek, K. (Behringwerke AG)
来源:AU 8944368; EP 0368131
合成路线图解说明:

The condensation of 9-cyanofluorene (I) with 3-(dimethylamino)propyl chloride (II) by means of sodium amide in refluxing THF gives 9-[3-(dimethyl amino)propyl]-9-cyanofluorene (III), which is hydrolyzed partially with hot sulfuric acid water.

参考文献No.45862
标题:Antiarrhythmic method
作者:Lacefield, W.B.; Simon, R.L. (Eli Lilly and Company)
来源:US 4197313
合成路线图解说明:

The condensation of 9-cyanofluorene (I) with 3-(dimethylamino)propyl chloride (II) by means of sodium amide in refluxing THF gives 9-[3-(dimethyl amino)propyl]-9-cyanofluorene (III), which is hydrolyzed partially with hot sulfuric acid water.

参考文献No.45863
标题:9-Carbamoyl-9-(2-cyanoethyl)fluorenes
作者:Lavagnino, E.R.; Pike, A.J.; Campbell, J.B. (Eli Lilly and Company)
来源:DD 158395; EP 0038676; GB 2074161; JP 1125363; US 4282170
合成路线图解说明:

The condensation of fluorene-9-carboxamide (IV) with acrylonitrile (V) by means of benzyltrimethylammonium hydroxide (VI) in hot dioxane gives 9-carbamoyl-9-(2-cyanoethyl)fluorene (VII), which is then hydrogenated and condensed with isopropylamine (VIII) and H2 over PtO2 with the same isopropylamine (VIII) as solvent.

参考文献No.62679
标题:Indecainide
作者:Serradell, M.N.; Sneddon, J.; Casta馿r, J.
来源:Drugs Fut 1985,10(2),121
合成路线图解说明:

The condensation of 9-cyanofluorene (I) with 3-(dimethylamino)propyl chloride (II) by means of sodium amide in refluxing THF gives 9-[3-(dimethyl amino)propyl]-9-cyanofluorene (III), which is hydrolyzed partially with hot sulfuric acid water.

合成路线图解说明:

The condensation of fluorene-9-carboxamide (IV) with acrylonitrile (V) by means of benzyltrimethylammonium hydroxide (VI) in hot dioxane gives 9-carbamoyl-9-(2-cyanoethyl)fluorene (VII), which is then hydrogenated and condensed with isopropylamine (VIII) and H2 over PtO2 with the same isopropylamine (VIII) as solvent.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us