【药物名称】LF-1695
化学结构式(Chemical Structure):
参考文献No.154555
标题:(Benzoylphenyl)piperidines: A new class of immunomodulators
作者:Ou, K.; Robin, J.; Bellamy, F.D.; Dodey, P.; Chazan, J.B.; Pascal, M.; Dutartre, P.
来源:J Med Chem 1991,34(5),1545-52
合成路线图解说明:

A more complete synthesis for LF-1695 has been reported: The reaction of 2-chloro-5-nitrobenzoic acid (I) with PCl5 in hot chlorobenzene gives the corresponding acyl chloride (II), which is condensed with chlorobenzene (III) by means of AlCl3, yielding 2,4'-dichloro-5-nitrobenzophenone (IV). The condensation of (IV) with 4-methylpiperidine (V) by means of K2CO3 at 150 C affords 4'-chloro-2-(4-methylpiperidin-1-yl)-5-nitrobenzophenone (VI), which is finally reduced with Fe or SnCl2 and HCl.

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