Tomelukast, LY-171883-药物合成数据库

【药物名称】Tomelukast, LY-171883

化学结构式(Chemical Structure):

参考文献No.	9141
标题:	Leukotriene antagonists
作者:	Marshall, W.S.; Verge, J.P. (Eli Lilly and Company)
来源:	EP 0108592

合成路线图解说明: The condensation of 2,4-dihydroxy-3-prop ylacetophenone (I) with 1 4-dibromobutane (II) by means of K2CO3 in refluxing acetone gives 4-(4 acetyl 3-hydroxy-2-propylphenoxy)butyl bromide (III), which is treated with NaCN in hot DMF to yield 5-(4 acetyl-3-hydroxy-2-propylphenoxy)pen tanenitrile (IV). Finally, this compound is cyclized with sodium azide by means of NH4Cl in DMF at 125 C.

参考文献No.	70125
标题:	LY-171883
作者:	Chu, S.S.
来源:	Drugs Fut 1985,10(8),632

合成路线图解说明: The condensation of 2,4-dihydroxy-3-prop ylacetophenone (I) with 1 4-dibromobutane (II) by means of K2CO3 in refluxing acetone gives 4-(4 acetyl 3-hydroxy-2-propylphenoxy)butyl bromide (III), which is treated with NaCN in hot DMF to yield 5-(4 acetyl-3-hydroxy-2-propylphenoxy)pen tanenitrile (IV). Finally, this compound is cyclized with sodium azide by means of NH4Cl in DMF at 125 C.