Pimobendan, UD-CG-115BS, UD-CG-115, Acardi-药物合成数据库

【药物名称】Pimobendan, UD-CG-115BS, UD-CG-115, Acardi

化学结构式(Chemical Structure):

参考文献No.	41911
标题:	Succimide derivatives, compositions and method of use
作者:	Ishizumi, K.; Antoku, F.; Asami, Y. (Sumitomo Chemical Co., Ltd.)
来源:	CA 1184915; EP 0082402

合成路线图解说明: The cyclization of methyl 3-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]butyrate (I) with hydrazine hydrate in refluxing acetic acid gives 4,5-dihydro-6-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]-5-methylpyridazin-3(2H)-one (II), which is reduced with H2 over Pd/C in ethanol yielding the corresponding amino derivative (III). Finally, this compound is cyclized in refluxing acetic acid.

合成路线图解说明: By condensation of norbornane-2,3-di-endo-carboxylic anhydride (I) with 1-(4-aminobutyl)-4-(2 pyrimidinyl)piperazine (II) in refluxing pyridine.

参考文献No.	66413
标题:	Pimobendan
作者:	Mannhold, R.
来源:	Drugs Fut 1985,10(7),570

合成路线图解说明: The cyclization of methyl 3-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]butyrate (I) with hydrazine hydrate in refluxing acetic acid gives 4,5-dihydro-6-[4-(4-methoxybenzoylamino)-3-nitrobenzoyl]-5-methylpyridazin-3(2H)-one (II), which is reduced with H2 over Pd/C in ethanol yielding the corresponding amino derivative (III). Finally, this compound is cyclized in refluxing acetic acid.