【药物名称】CL-232468
化学结构式(Chemical Structure):
参考文献No.46016
标题:1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
作者:Durr, F.E.; Murdock, K.C. (American Cyanamid Co.)
来源:US 4197249
合成路线图解说明:

By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.

参考文献No.65761
标题:CL-232468
作者:Casta馿r, J.; Arrigoni-Martelli, E.; Serradell, M.N.
来源:Drugs Fut 1985,10(5),376
合成路线图解说明:

By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.

参考文献No.607186
标题:Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
作者:Murdock, K.C.; Child, R.G.; Fabio, P.F.; Angier, R.B.; Wallace, R.E.; Durr, F.E.; Citarella, R.V.
来源:J Med Chem 1979,22(9),1024
合成路线图解说明:

By condensation of 2,3-dihydro-1,4-dihydroxyanthraquinone (I) with N-(aminoethyl)ethanolamine (II) in refluxing ethanol, followed by oxidation with air and treatment with acetic acid.

合成路线图解说明:

By condensation of 1,4,5,8-tetrahydroxyanthraquinone (I) with ethylenediamine (II) in hot tetramethylethylenediamine.

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