Dromoprednate, Ro-12-7024-药物合成数据库

【药物名称】Dromoprednate, Ro-12-7024

化学结构式(Chemical Structure):

参考文献No.	39867
标题:	D-Homopregnanes
作者:	F黵st, A.; Alig, L.; Kerb, U.; M黮ler, M.; Wiechert, R.; Kieslich, K. (Hoffmann-La Roche, Inc.)
来源:	US 4202841

合成路线图解说明: The partial acylation of 11beta,17a alpha(dihydroxy-D-homopregna-1,4-diene 3,20-dione (I) with 2,2-dichloroacetyl chloride gives the corresponding compound (II), which is acylated again with butyric anhydride yielding 17a alpha-butyryloxy-11beta-dichloroacetoxy-D-homopregna-1,4-diene-3,20-dione (III). Finally, this compound is hydrolyzed partially with aqueous NH4OH and methanol.

参考文献No.	62678
标题:	Domoprednate
作者:	Baines, A.; M黮ler, M.
来源:	Drugs Fut 1987,12(2),118

合成路线图解说明: The partial acylation of 11beta,17a alpha(dihydroxy-D-homopregna-1,4-diene 3,20-dione (I) with 2,2-dichloroacetyl chloride gives the corresponding compound (II), which is acylated again with butyric anhydride yielding 17a alpha-butyryloxy-11beta-dichloroacetoxy-D-homopregna-1,4-diene-3,20-dione (III). Finally, this compound is hydrolyzed partially with aqueous NH4OH and methanol.