Fludarabine phosphate, SHT-586, NSC-312887, 2-F-ara-AMP, 2-Fluoro-ara-AMP, Beneflur, Fludara-药物合成数据库

【药物名称】Fludarabine phosphate, SHT-586, NSC-312887, 2-F-ara-AMP, 2-Fluoro-ara-AMP, Beneflur, Fludara

化学结构式(Chemical Structure):

参考文献No.	45856
标题:	Prodrug derivatives of 9-beta-D-arabinofuranosyl-2-fluoroadenine
作者:	Montgomery, J.A.; Shortnacy, A.T. (US Department of Health & Human Services)
来源:	US 4357324

合成路线图解说明: The reaction of 9-beta-D-arabinofuranosyl-2-fluoroadenine (I) with triethyl phosphate and POCl3 gives 9-beta-D-arabinofuranosyl-2-fluoroadenine-5'-(diethylphosphate) (II), which is hydrolyzed with Domez 1x8 (formated form) resin.

参考文献No.	62053
标题:	Fludarabine phosphate
作者:	Serradell, M.N.; Casta馿r, J.; Hopkins, S.J.
来源:	Drugs Fut 1985,10(1),20

合成路线图解说明: The reaction of 9-beta-D-arabinofuranosyl-2-fluoroadenine (I) with triethyl phosphate and POCl3 gives 9-beta-D-arabinofuranosyl-2-fluoroadenine-5'-(diethylphosphate) (II), which is hydrolyzed with Domez 1x8 (formated form) resin.