【药物名称】Bambuterol, KWD-2183, Bambec
化学结构式(Chemical Structure):
参考文献No.42029
标题:Bronchospamolytic carbamate derivatives
作者:Olsson, O.A.T.; Svensson, L.A.; Wetterlin, K.I.L. (Draco L鋕emedel AB)
来源:DD 202001; EP 0043807; JP 8240453; US 4419364; US 4451663
合成路线图解说明:

The reaction of 3,5-dihydroxyacetophenone (I) with N,N-dimethylcarbamoyl chloride (II) in hot pyridine gives 3,5-bis(N,N-dimethylcarbamoyloxy) acetophenone (III), which is brominated with Br2 in dioxane yielding 3,5-bis(N,N-dimethylcarbamoyloxy)phenacyl bromide (IV). The condensation of (IV) with N benzyl-tert butylamine (V) in refluxing acetone affords the corresponding w-amino derivative (VI), which is finally hydrogenated with H2 over Pd/C in ethanol.

参考文献No.70648
标题:Bambuterol
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(7),553
合成路线图解说明:

The reaction of 3,5-dihydroxyacetophenone (I) with N,N-dimethylcarbamoyl chloride (II) in hot pyridine gives 3,5-bis(N,N-dimethylcarbamoyloxy) acetophenone (III), which is brominated with Br2 in dioxane yielding 3,5-bis(N,N-dimethylcarbamoyloxy)phenacyl bromide (IV). The condensation of (IV) with N benzyl-tert butylamine (V) in refluxing acetone affords the corresponding w-amino derivative (VI), which is finally hydrogenated with H2 over Pd/C in ethanol.

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