Pipequaline, PK-8165-药物合成数据库

【药物名称】Pipequaline, PK-8165

化学结构式(Chemical Structure):

参考文献No.	47467
标题:	2-(4-Piperidyl)-1-(4-4-quinolyl)-ethanone derivs., intermediates in and process for their preparation, and their use as medicines
作者:	Champseix, A.A.; Lefur, G.R.; Renault, C.L.A. (Pharmindustrie)
来源:	EP 0031753

合成路线图解说明: The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III), which is then reduced with hydrazine at 180 C.

参考文献No.	71695
标题:	PK-8165 and PK-9084
作者:	Blancafort, P.; McGillion, F.B.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1982,7(9),648

合成路线图解说明: The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with ethyl N-benzoylpiperidyl-4-acetate (II) by means of potassium tert-butylate in THF gives 2-phenyl-4-(4-piperidylacetyl)quinone (III), which is then reduced with hydrazine at 180 C.

合成路线图解说明: The reaction of ethyl 2-phenylquinoline-4-carboxylate (I) with N-benzoylpipepidine-3-acetic acid ethyl ester (II) by means of potassium hydride in THF gives 2-phenyl-4-[2-(3-piperidyl)acetyl]quinoline (III), which is reduced with hydrazine in dietyleneglycol at 180 C.