【药物名称】Demetacin, Delmetacin, UR-2310
化学结构式(Chemical Structure):
参考文献No.71726
标题:Delmetacin
作者:Francia, E.; Garc韆 Rafanell, J.
来源:Drugs Fut 1983,8(9),764
合成路线图解说明:

The phenylhydrazone of benzaldehyde (I) is obtained in the usual way, phenylhydrazine (A) with benzaldehyde (B), which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III). Finally, this compound is condensed with levulinic acid (IV) at high temperature.

参考文献No.900143
标题:Procedimiento de obtenci髇 del 醕ido 1-benzoil-2-metilindol-3-ac閠ico
作者:Franc韆, E.; Mar韓, A. (Uriach & Cia S.A.)
来源:ES 471436
合成路线图解说明:

The phenylhydrazone of benzaldehyde (I) is obtained in the usual way, phenylhydrazine (A) with benzaldehyde (B), which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III). Finally, this compound is condensed with levulinic acid (IV) at high temperature.

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