Nizatidine, ZE-101, ZL-101, LY-139037, Zanizal, Nizax, Acinon, Axid-药物合成数据库

【药物名称】Nizatidine, ZE-101, ZL-101, LY-139037, Zanizal, Nizax, Acinon, Axid

化学结构式(Chemical Structure):

参考文献No.	46488
标题:	N-Methyl-N'-2-[[(2-dimethylaminomethyl)-4-thiazolyl]methylthio]ethyl-2-nitro-1,1-ethenediamine
作者:	Pioch, R.P. (Eli Lilly and Company)
来源:	EP 0049618; GB 2084581; JP 57091980; US 4375547

合成路线图解说明: The cyclization of dimethylaminothioacetamide (I) with ethyl bromopyruvate (II) in refluxing ethanol gives ethyl 2-(dimethylaminomethyl)-4-thiazolecarboxylate (III), which is reduced with lithium triethyl borohydride in THF yielding 2-(dimethylaminomethyl)-4-thiazolemethanol (IV). The condensation of (IV) with 2-aminoethanethiol (V) by means of 48% HBr affords 2-(dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (VI), which is finally condensed with 1-(methylthio)-2-nitro-N-methylethyleneamine (VII) in water.

参考文献No.	49418
标题:	Nizatidine
作者:	Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1984,9(9),655

合成路线图解说明: The cyclization of dimethylaminothioacetamide (I) with ethyl bromopyruvate (II) in refluxing ethanol gives ethyl 2-(dimethylaminomethyl)-4-thiazolecarboxylate (III), which is reduced with lithium triethyl borohydride in THF yielding 2-(dimethylaminomethyl)-4-thiazolemethanol (IV). The condensation of (IV) with 2-aminoethanethiol (V) by means of 48% HBr affords 2-(dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (VI), which is finally condensed with 1-(methylthio)-2-nitro-N-methylethyleneamine (VII) in water.