【药物名称】Metuclazepam, Brometazepam, Metaclazepam, KC-2547, KA-2547, Talis
化学结构式(Chemical Structure):
参考文献No.46777
标题:Process for making benzodiazepine derivatives
作者:Milkowski, W.; Budden, R.; Funke, S.; Hueschens, R.; Liepmann, H.; Stuehmer, W.; Zeugner, H. (Kali-Chemie AG)
来源:US 4098786
合成路线图解说明:

Metaclazepam can be prepared by a cyclization reaction of the acyl diamine (I) with phosphorus oxychloride, thus yielding a mixture of two isomeric compounds (II) and (III). This mixture is directly converted into 1-methyl-2-methoxymethyl-5-(2'-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine (IV) by means of sodium methoxide in methanol. The nucleophilic attack of the methoxide ion on compound (III) affords nearly complete ring contraction to form (IV) as the main product. Finally, (IV) is halogenated by treatment with N-bromosuccinimide in methylene chloride at reflux temperature.

参考文献No.49407
标题:Metaclazepam
作者:Ruhland, M.; Engelbart, S.; Zeugner, H.
来源:Drugs Fut 1982,7(8),577
合成路线图解说明:

Metaclazepam can be prepared by a cyclization reaction of the acyl diamine (I) with phosphorus oxychloride, thus yielding a mixture of two isomeric compounds (II) and (III). This mixture is directly converted into 1-methyl-2-methoxymethyl-5-(2'-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine (IV) by means of sodium methoxide in methanol. The nucleophilic attack of the methoxide ion on compound (III) affords nearly complete ring contraction to form (IV) as the main product. Finally, (IV) is halogenated by treatment with N-bromosuccinimide in methylene chloride at reflux temperature.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us