Xamoterol fumarate, TI-31, ICI-118587, Sepan, Corwin-药物合成数据库

【药物名称】Xamoterol fumarate, TI-31, ICI-118587, Sepan, Corwin

化学结构式(Chemical Structure):

参考文献No.	46776
标题:	Morpholine carboxamides and use thereof
作者:	Main, B.G.; Barlow, J.J. (AstraZeneca plc)
来源:	FR 2391997; JP 53147038; US 4143140; US 4172150

合成路线图解说明: The reaction of 1-(p-benzyloxyphenoxy)-2,3-epoxypropane (I) with 4-[N-(2-aminoethyl)carbamoyl]morpholine (II) by means of KOH in isopropanol gives 1-(p-benzyloxyphenoxy)-3-[2-(morpholinocarbonamido)ethylamino]-2-propanol (III), which is debenzylated by treatment with H2 over Pd/C in ethanol acetic acid and treated with a solution of fumaric acid in ethanol.

参考文献No.	70144
标题:	ICI-118,587
作者:	Blancafort, P.; Serradell, M.N.; Thorpe, P.J.; Casta馿r, J.
来源:	Drugs Fut 1982,7(8),571

合成路线图解说明: The reaction of 1-(p-benzyloxyphenoxy)-2,3-epoxypropane (I) with 4-[N-(2-aminoethyl)carbamoyl]morpholine (II) by means of KOH in isopropanol gives 1-(p-benzyloxyphenoxy)-3-[2-(morpholinocarbonamido)ethylamino]-2-propanol (III), which is debenzylated by treatment with H2 over Pd/C in ethanol acetic acid and treated with a solution of fumaric acid in ethanol.