【药物名称】Menogaril, TUT-7, U-52047, 7-Omen, NSC-269148, Tomosar
化学结构式(Chemical Structure):
参考文献No.70123
标题:7-Con-O-methylnogarol
作者:Cabanillas, F.; Casta馿r, J.
来源:Drugs Fut 1980,5(8),400
合成路线图解说明:

The hydrolysis of nogalomycin (I) with aqueous KOH gives nogalomycinic acid (II), which by treatment with DMF in methanol at room temperature yields nogamycine (III). Finally, compound (III) is methanolyzed with HCl in refluxing methanol.

参考文献No.701418
标题:
作者:Wiley, P.F.; Houser, D.J.
来源:US 4086245
合成路线图解说明:

The hydrolysis of nogalomycin (I) with aqueous KOH gives nogalomycinic acid (II), which by treatment with DMF in methanol at room temperature yields nogamycine (III). Finally, compound (III) is methanolyzed with HCl in refluxing methanol.

参考文献No.800495
标题:Nogalamycin analogs havin improved antitumor activity
作者:Wiley, P.F.; et al.
来源:J Antibiot 1977,30628-629
合成路线图解说明:

The hydrolysis of nogalomycin (I) with aqueous KOH gives nogalomycinic acid (II), which by treatment with DMF in methanol at room temperature yields nogamycine (III). Finally, compound (III) is methanolyzed with HCl in refluxing methanol.

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